TABLE 3

Survival of mice after ChE administration and exposure to 1 and 2.5 LD₅₀ of soman

Administered Soman	Administered ChE
Administered Soman		None	rHuAChE	HuBChE
1 LD₅₀
Administered enzyme (nmol/mouse)		1.2	1.2
Administered soman (nmol/mouse)	1.2	1.2	1.2
Survival (live/total)	60% (3/5)^a	100% (5/5)	100% (5/5)
2.5 LD₅₀
Administered enzyme (nmol/mouse)		1.2	1.2
Administered soman (nmol/mouse)	3	3	3
Survival (live/total)	0% (0/5)	100% (5/5)^a	20% (1/5)^b

↵ a Surviving animals displayed mild symptoms of toxicity: mild tremors and Straub tail.
↵ b Surviving animals displayed severe symptoms of toxicity: severe tremors, Straub tail, salivation, and respiratory distress.