Administered OP Agent | Administered ChE | ||||
---|---|---|---|---|---|
None | rHuAChE | HuBChE | |||
2.5 LD50 sarin | |||||
Administered enzyme (nmol/mouse) | 2.6 | 2.6 | |||
Administered OP (nmol/mouse) | 6.5 | 6.5 | 6.5 | ||
Survival (live/total) | 0% (0/5) | 80% (4/5)a | 0% (0/5) | ||
2.5 LD50 VX | |||||
Administered enzyme (nmol/mouse) | 3.2 | 3.2 | |||
Administered OP (nmol/mouse) | 4 | 4 | 4 | ||
Survival (live/total) | 0% (0/5) | 100% (5/5) | 60% (3/5)a |
↵ a Surviving animals displayed severe symptoms of toxicity: severe tremors, Straub tail, salivation, and respiratory distress.