Protection of mice against OP agents by PEGylated rHuAChE: survival of mice after exposure to 2.5 LD50 soman
Animals challenged with soman were pretreated with CBDP 1 h before enzyme administration.
Administered ChE | |||||
|---|---|---|---|---|---|
| None | rHuAChE | PEG-rHuAChE | |||
| Administered enzyme (nmol/mouse) | 1.2 | 1.2 | |||
| Administered soman (nmol/mouse) | 3 | 3 | 3 | ||
| Survival (live/total) | 0% (0/5) | 100% (5/5)a | 100% (5/5)a | ||
↵ a Surviving animals displayed mild symptoms of toxicity: mild tremors and Straub tail.