Growth inhibition effect of a series of Hsp90 inhibitors in MDA468 and MDA468/NQ16 cells following treatment (4 h)
Compound | IC50 (μM) | IC50 -Fold Difference | ||||||
|---|---|---|---|---|---|---|---|---|
| MDA468 | MDA468 + ES936 | NQ16 | NQ16 + ES936 | |||||
| GM | 0.063 ± 0.011 | 0.064 ± 0.013 | 0.023 ± 0.0003 | 0.057 ± 0.01 | 3 | |||
| 17AAG* | 10.05 ± 1.07 | 7.34 ± 1.04 | 0.86 ± 0.16 | 7.67 ± 1.36 | 12 | |||
| 17AG | 6.77 ± 0.77 | 6.62 ± 0.42 | 1.1 ± 0.11 | 5.61 ± 1.05 | 6 | |||
| 17DMAG | 2.06 ± 0.25 | 1.9 ± 0.19 | 0.22 ± 0.05 | 1.81 ± 0.2 | 9 | |||
| 17AEP-GA | 2.69 ± 0.08 | 2.68 ± 0.12 | 0.65 ± 0.04 | 2.59 ± 0.18 | 4 | |||
| Radicicol* | 3.81 ± 0.44 | 4.04 ± 0.35 | 1 | |||||
↵* Data for 17AAG and radicicol have been reported previously (Guo et al., 2005).