Alignment of amino acid sequence in loop D of the ACh binding site of vertebrate and insect nicotinic acetylcholine receptors
Subunits | Amino Acid Number of Chicken β2 Subunita | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 73 | 74 | 75 | 76 | 77 | 78 | 79 | 80 | 81 | 82 | ||||||||||
| Vertebrates | |||||||||||||||||||
| Chicken α7 | N | I | W | L | Q | M | Y | W | T | D | |||||||||
| Chicken β2 | N | V | W | L | T | Q | E | W | E | D | |||||||||
| Chicken β4 | N | V | W | L | N | Q | E | W | I | D | |||||||||
| Human β2 | N | V | W | L | T | Q | E | W | E | D | |||||||||
| Human β4 | N | V | W | L | K | Q | E | W | T | D | |||||||||
| Human δ | N | V | W | I | E | H | G | W | T | D | |||||||||
| Human ϵ | S | V | W | I | G | I | D | W | Q | D | |||||||||
| Rat β1 | K | V | Y | L | D | L | E | W | T | D | |||||||||
| Rat β2 | N | V | W | L | T | Q | E | W | E | D | |||||||||
| Rat β4 | S | I | W | L | K | Q | E | W | T | D | |||||||||
| Insects | |||||||||||||||||||
| Fruit fly Dβ1 | N | V | W | L | R | L | V | W | Y | D | |||||||||
| Fruit fly Dβ2 | N | L | W | V | K | Q | R | W | F | D | |||||||||
| Fruit fly Dβ3 | H | C | W | L | N | L | R | W | R | D | |||||||||
| Locusta migratoria β | N | V | W | L | R | L | V | W | N | D | |||||||||
| Myzus persicae β1 | N | V | W | L | R | L | V | W | R | D | |||||||||
| Heliothis virescens β1 | N | V | W | L | R | L | V | W | M | D | |||||||||
↵ a Residue numbering is from the start methionine.