Relative liver weight and lipids in mice treated with LXR ligands for 3 days
Data are expressed as mean ± S.E.M.
Treatment | Dose | n | LW/BW | TC | TG |
|---|---|---|---|---|---|
| mg/kg | mg/g | ||||
| LXRα KO mice | |||||
| Vehicle | 6 | 52.0 ± 1.7 | 4.5 ± 0.22 | 8.3 ± 0.49 | |
| TO901317 | 5 | 6 | 50.2 ± 1.1 | 4.2 ± 0.17 | 8.3 ± 0.21 |
| TO901317 | 50 | 6 | 55.5 ± 1.1* | 4.2 ± 0.17 | 8.3 ± 0.42 |
| GW3965 | 10 | 6 | 52.4 ± 1.0 | 4.5 ± 0.22 | 9.0 ± 0.37 |
| GW3965 | 50 | 6 | 51.4 ± 0.60 | 4.5 ± 0.34 | 9.8 ± 0.48** |
| Wild-type Mice | |||||
| vehicle | 6 | 42.5 ± 5.8 | 4.0 ± 0.45 | 11.7 ± 0.99 | |
| TO901317 | 5 | 6 | 45.1 ± 2.3 | 4.0 ± 0.00 | 12.0 ± 1.05 |
| TO901317 | 50 | 6 | 46.6 ± 3.4* | 4.0 ± 0.26 | 14.3 ± 1.2 |
| GW3965 | 10 | 6 | 42.8 ± 2.9 | 4.0 ± 0.00 | 14.8 ± 1.6 |
| GW3965 | 50 | 6 | 44.2 ± 2.3 | 4.0 ± 0.00 | 14.3 ± 0.56 |
*p < 0.05; **p < 0.01. n = 6 per group.
LW/BW, liver weight (in milligrams)/body weight (in grams).