HIF-1 target genes
Function | Gene (abbreviation) | Reference |
|---|---|---|
| Erythropoiesis/ iron metabolism | Erythropoietin (EPO) | Semenza et al., 1991 |
| Transferrin (Tf) | Rolfs et al., 1997 | |
| Transferrin receptor (Tfr) | Bianchi et al., 1999 | |
| Ceruloplasmin | Lok and Ponka, 1999 | |
| Angiogenesis | Vascular endothelial growth factor (VEGF) | Levy et al., 1995 |
| Endocrine-gland-derived VEGF (EG-VEGF) | LeCouter et al., 2001 | |
| Leptin (LEP) | Grosfeld et al., 2002 | |
| Transforming growth factor-β3 (TGF-β3) | Scheid et al., 2002 | |
| Vascular tone | Nitric oxide synthase (NOS2) | Melillo et al., 1995 |
| Heme oxygenase 1 | Lee et al., 1997 | |
| Endothelin 1 (ET1) | Hu et al., 1998 | |
| Adrenomedulin (ADM) | Nguyen and Claycomb, 1999 | |
| α1B-Adrenergic receptor | Eckhart et al., 1997 | |
| Matrix metabolism | Matrix metalloproteinases (MMPs) | Ben-Yosef et al., 2002 |
| Plasminogen activator receptors and inhibitors (PAIs) | Kietzmann et al., 1999 | |
| Collagen prolyl hydroxylase | Takahashi et al., 2000 | |
| Glucose metabolism | Adenylate kinase-3 | O'Rourke et al., 1996 |
| Aldolase-A,C (ALDA,C) | Semenza et al., 1996 | |
| Carbonic anhydrase-9 | Wykoff et al., 2000 | |
| Enolase-1 (ENO1) | Semenza et al., 1996 | |
| Glucose transporter-1,3 (GLU1,3) | Chen et al., 2001 | |
| Glyceraldehyde phosphate dehydrogenase (GAPDH) | Graven et al., 1999 | |
| Hexokinase 1,2 (HK1,2) | Mathupala et al., 2001 | |
| Lactate dehydrogenase-A (LDHA) | Semenza et al., 1996 | |
| Pyruvate kinase M (PKM) | Semenza et al., 1994 | |
| Phosphofructokinase L (PFKL) | Semenza et al., 1994 | |
| Phosphoglycerate kinase 1 (PGK1) | Semenza et al., 1994 | |
| 6-phosphofructo-2-kinase/gructose-2,6-bisphosphate-3 (PFKFB3) | Minchenko et al., 2002 | |
| Cell proliferation/survival | Insulin-like growth factor-2 (IGF2) | Feldser et al., 1999 |
| Transforming growth factor-α (TGF- α) | Krishnamachary et al., 2003 | |
| Adrenomedullin (ADM) | Cormier-Regard et al., 1998 | |
| Apoptosis | Bcl-2/adenovirus EIB 19kD-interacting protein 3 (BNip3) | Carrero et al., 2000 |
|
| Nip3-like protein X (NIX) |
Bruick, 2000
|