Effects of UCL2077 on action potential shapes and sAHP kinetics in cultured hippocampal pyramidal neurons
Before Application of UCL2077 | In the Presence of UCL2077 | |
|---|---|---|
| Action potential width (1 μM) | 1.24 ± 0.2 ms (n = 5) | 1.42 ± 0.2 ms (n = 5) |
| Action potential width (3 μM) | 1.90 ± 0.5 ms (n = 3) | 2.73 ± 0.6 ms (n = 3)* |
| Action potential amplitude (3 μM) | 68.9 ± 4.0 mV (n = 3) | 66.7 ± 1.6 mV (n = 3) |
| Decay time constant (1 μM) | 1.15 ± 0.4 s (n = 5) | 0.93 ± 0.4 s (n = 5) |
| Time to peak (1 μM) | 0.50 ± 0.02 s (n = 5) | 0.53 ± 0.02 s (n = 5) |
↵* P < 0.05.