Effects of UCL2077 on action potential and sAHP kinetics measured from hippocampal neurons present in the slice preparation.
Before Application of UCL2077 | In the Presence of UCL2077 | |
|---|---|---|
| Action potential width | 1.39 ± 0.5 ms (n = 8) | 1.31 ± 0.4 ms (n = 8) |
| Action potential threshold | −49.1 ± 2.4 mV (n = 5) | −48.2 ± 2.0 mV (n = 5) |
| Action potential amplitude | 74.8 ± 2.2 mV (n = 8) | 69.1 ± 1.9 mV (n = 8) |
| Decay time constant | 2.31 ± 0.1 s (n = 8) | 2.46 ± 0.3 s (n = 8) |
| Time to peak | 0.56 ± 0.02 s (n = 8) | 0.62 ± 0.06 (n = 8) |
*P < 0.05