TABLE 1

Compounds tested and their relative binding affinities for the two β-adrenergic subtypes

The data from Hoffmann et al. (2004) and Ponicke et al. (2002) are from ¹²⁵I-cyanopindolol binding, and those from Pauwels et al. (1988) are from [³H]CGP-12177 binding.

Ligand	K_i			Reference
Ligand		β₁AR	β₂AR	Reference
	nM
Isoproterenol	224	458	Hoffmann et al., 2004
Labetalol	24	19	Pauwels et al., 1988
Bucindolol	1.6	1.2	Ponicke et al., 2002
Carvedilol	1.7	1.1	Hoffmann et al., 2004
	0.81	0.96	Ponicke et al., 2002
	0.24	0.19	Pauwels et al., 1988
Propranolol	1.8	0.8	Hoffmann et al., 2004
	4.12	0.96	Ponicke et al., 2002
	2.8	0.62	Pauwels et al., 1988
Metoprolol	47	2960	Hoffmann et al., 2004
Bisoprolol	22.4	1150	Hoffmann et al., 2004
Atenolol	388	8140	Hoffmann et al., 2004
	396	7493	Pauwels et al., 1988