TABLE 2

EC50 on cAMP and on MAPK of compounds tested on β1AR

Experimental data from Figs. 1A and 2B presented as mean ± S.E.M.


Ligand

EC50
cAMP
MAPK
nM
Isoproterenol 4.61 ± 2.08 2147.17 ± 1162
Labetalol 5.10 ± 3.42 N.D.
Bucindolol 2.77 ± 1.16 14.25 ± 9.06
Carvedilol 273.19 ± 212.52 74.59 ± 39.90
Propranolol 33.31 ± 12.80 32.68 ± 19.02
Metoprolol 141.68 ± 87.71 N.D.
Bisoprolol 42.26 ± 18.20 N.D.
Atenolol
312.47 ± 170.00
N.D.
  • N.D., not determined.