TABLE 3

Emax on cAMP and on MAPK of compounds tested on β1AR.

Experimental data from Figs. 1B and 2A, presented as maximal response ± S.E.M. Data are expressed as a percentage of the isoproterenol-stimulated response unless otherwise specified.


Ligand

Emax
cAMP
MAPK
Isoproterenol 100 100
Labetalol 33 ± 1 6.3 ± 1.4
Bucindolol 44 ± 4 25.5 ± 5.3
Carvedilol 35 ± 2 27.8 ± 6.0
Propranolol −32 ± 7a 22.0 ± 4.4
Metoprolol −69 ± 7a 2.4 ± 0.4
Bisoprolol −72 ± 7a 2.9 ± 1.6
Atenolol
−63 ± 7a
5.4 ± 1.3
  • a Forskolin response inhibition.