TABLE 5

E_max on cAMP and on MAPK of compounds tested on β₂AR

Experimental data from Fig. 3B and 4A, presented as maximal response ± S.E.M. Data are expressed as percentage of the isoproterenol-stimulated response unless otherwise specified.

	E_max
Ligand	cAMP	MAPK
Isoproterenol	100	100
Labetalol	31.5 ± 1.7	64.1 ± 7.3
Bucindolol	−2.8 ± 1.8^a	64.8 ± 8.3
Carvedilol	−6.7 ± 7.0^a	38.12 ± 6.4
Propranolol	−43.9 ± 7.6^a	40.6 ± 4.5
Metoprolol	−59.2 ± 9.0^a	−41.2 ± 11.5^b
Bisoprolol	−59.4 ± 12.0^a	−51.6 ± 7.7^b
Atenolol	−59.5 ± 10.8^a	−55.8 ± 9.8^b

↵ a Forskolin response inhibition.
↵ b PMA response inhibition.