TABLE 4

EC50 on cAMP and on MAPK of compounds tested on β2AR Experimental data from Figs. 3A and 4B presented as mean ± S.E.M.


Ligand

EC50
cAMP
MAPK
nM
Isoproterenol 4.99 ± 2.08 214.21 ± 90.73
Labetalol 6.76 ± 3.42 11.65 ± 5.58
Bucindolol > 10,000 0.95 ± 0.32
Carvedilol > 10,000 6.88 ± 4.09
Propranolol 2.32 ± 0.37 8.64 ± 2.84
Metoprolol 294.20 ± 95.58 N.D.
Bisoprolol 305.50 ± 131.48 N.D.
Atenolol
2400.80 ± 1342.00
N.D.
  • N.D., not determined.