pIC50 values for peptides in competition for 125I-rAmy binding to COS-7 cells contransfected with hCTRa and RAMPs Data are represented as mean ± S.E.M. (n ≥ 4).
hCGRPα | rAmy | hCT | sCT | |
|---|---|---|---|---|
| CTRa + RAMP3 | 7.00 ± 0.13 | 8.01 ± 0.14 | 6.96 ± 0.13 | 8.69 ± 0.12 |
| CTRa + RAMP3Δ-C | 6.91 ± 0.16 | 7.95 ± 0.11 | 7.55 ± 0.20* | 8.50 ± 0.16 |
↵* Significantly different from RAMP3 (P < 0.05; unpaired t test).