TABLE 3

pEC₅₀ values for peptide-induced cAMP production in COS-7 cells contransfected with hCTRa and RAMPs Data are represented as mean ± S.E.M. (n ≥ 7).

	hCGRPα	rAmy	hCT	sCT
CTRa + vector	6.88 ± 0.10	7.13 ± 0.19	9.43 ± 0.17	10.10 ± 0.22
CTRa + RAMP1	8.45 ± 0.15^†	8.47 ± 0.16^†	9.00 ± 0.14	10.12 ± 0.23
CTRa + RAMP1Δ-C	7.18 ± 0.13^*	6.95 ± 0.18^*	8.92 ± 0.13	10.16 ± 0.21
CTRa + c-Myc-RAMP1	8.50 ± 0.36^†	8.44 ± 0.29^†	8.72 ± 0.15	9.77 ± 0.21
CTRa + c-Myc-RAMP1Δ-C	6.78 ± 0.38^*	6.89 ± 0.32^*	8.42 ± 0.23^†	9.35 ± 0.29
CTRa + RAMP2	7.11 ± 0.17	7.16 ± 0.18	9.39 ± 0.19	9.70 ± 0.25
CTRa + RAMP2Δ-C	6.90 ± 0.24	7.40 ± 0.20	8.32 ± 0.17^*^†	10.37 ± 0.22
CTRa + RAMP3	7.62 ± 0.19	8.61 ± 0.15^†	8.17 ± 0.20^†	9.58 ± 0.27
CTRa + RAMP3Δ-C	6.57 ± 0.26^*	7.88 ± 0.17	9.21 ± 0.18^*	9.94 ± 0.23

↵* Significantly different from full-length RAMP (P < 0.05; one-way analysis of variance).
↵† Significantly different from vector control.