IC50 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IBMX | Tadalafil | Sildenafil-Based | Vardenafil-Based | |||||||||||
Sildenafil | UK-122764 | Vardenafil | Demethyl-Vardenafil | BAY-51-187 | ||||||||||
μM | nM | nM | nM | nM | nM | nM | ||||||||
PDE5 | 4.6 ± 0.7 | 2.9 ± 0.3 | 2.3 ± 0.4 | 5.4 ± 0.5 | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.4 ± 0.3 | |||||||
PDE5Δ1-321 | 4.5 ± 0.8 | 3.6 ± 0.4 | 2.5 ± 0.4 | 5.5 ± 1.5 | 0.6 ± 0.2 | 0.6 ± 0.2 | 0.5 ± 0.1 | |||||||
PDE5Δ1-419 | 4.4 ± 0.6 | 3.8 ± 1.1 | 2.6 ± 0.4 | 5.1 ± 1.9 | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.4 ± 0.2 | |||||||
PDE5Δ1-465 | 4.8 ± 2.4 | 3.6 ± 1.3 | 3.0 ± 0.5 | 5.5 ± 0.8 | 2.7 ± 0.5 | 5.6 ± 1.2 | 3.1 ± 0.8 | |||||||
C domain (Δ1-534) |
| 4.3 ± 1.2 | 3.6 ± 0.5 | 2.8 ± 0.1 | 5.1 ± 0.8 | 2.9 ± 0.3 | 3.2 ± 0.5 | 2.9 ± 0.4 |