Carbachol | AC-260584 | Clozapine | N-Desmethylclozapine | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Eff | pEC50 | Shift | Eff | pEC50 | Shift | Eff | pEC50 | Shift | Eff | pEC50 | Shift | |||||||||
% | % | % | % | |||||||||||||||||
M1 WT | 100 ± 4 | 6.3 ± 0.2 | 1 | 100 ± 7 | 7.3 ± 0.1 | 1 | N.R. | N.D. | 55 ± 8 | 7.0 ± 0.2 | 1 | |||||||||
W101A | >75 | <4.5 | >30 | 112 ± 6 | 8.8 ± 0.1 | 0.03 | 57 ± 11 | 8.1 ± 0.1 | 54 ± 11 | 6.5 ± 0.2 | 6 | |||||||||
Y106A | N.R. | N.D. | 110 ± 22 | 6.6 ± 0.1 | 4 | 95 ± 21 | 8.9 ± 0.2 | 40 ± 4 | 6.7 ± 0.1 | 3 | ||||||||||
S109A | >100 | <4.5 | >30 | 85 ± 11 | 7.1 ± 0.3 | 1 | N.R. | N.D. |
| 47 ± 17 | 6.7 ± 0.6 | 4 |
N.R., no response (i.e., the measured response was not significantly different from baseline); N.D., not determined.