Agonist potencies (pEC50) for stimulation of cAMP production by mutant or WT AMY, CGRP, or AM receptors.
Data are presented as mean ± S.E.M. The values in parentheses represent the number of individual experiments performed.
rAmy | hβCGRP | hαCGRP | hAM | |
|---|---|---|---|---|
| WT AMY1(a) | 8.98 ± 0.19 (5) | 9.17 ± 0.41 (3) | ||
| W74A AMY1(a) | 9.05 ± 0.37 (3) | 8.84 ± 0.28 (4) | ||
| W74K AMY1(a) | 9.27 ± 0.12 (5) | 9.44 ± 0.09 (3) | ||
| WT AMY3(a) | 9.17 ± 0.05 (4) | |||
| E74W AMY3(a) | 8.93 ± 0.06 (4)* | |||
| WT CGRP1 | 9.76 ± 0.14 (11) | 9.52 ± 0.08 (12) | ||
| W74A CGRP1 | 9.97 ± 0.1 (4) | 9.7 ± 0.06 (4) | ||
| W74K CGRP1 | 9.85 ± 0.07 (4) | 9.73 ± 0.09 (4) | ||
| WT AM2 | 7.36 ± 0.14 (5) | 6.67 ± 0.2 (4) | 9.21 ± 0.08 (4) | |
| E74W AM2 | 7.34 ± 0.11 (3) | 7.01 ± 0.16 (3) | 7.91 ± 0.19 (4)††† | |
| E74Q AM2 | 8.88 ± 0.07 (4)* | |||
| E74D AM2 | 8.94 ± 0.10 (4) | |||
| E74K AM2 |
|
|
| 8.72 ± 0.10 (4)* |