125I-CXCL1/GROα as Radioligand | 125I-CXCL10/IP10 as Radioligand | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ORF74-HHV8 | [R208H;R212H] | Ago. Fmut | ORF74-HHV8 | [R208H;R212H] | Inv. Fmut | wt Fligand | [R208H;R212H] Fligand | |||||||||||||
IC50 | n | IC50 | n | IC50 | n | IC50 | n | |||||||||||||
nM | nM | nM | nM | |||||||||||||||||
Agonists | ||||||||||||||||||||
CXCL1/GROα | 0.09 ± 0.02 a | 16 | 0.52 ± 0.10 b | 16 | 5.8 | 0.81 ± 0.14 | 7 | 111 ± 38 | 7 | 136 | 9.2 | 213 | ||||||||
CXCL2/GROβ | 0.22 ± 0.05 | 5 | 2.1 ± 0.36 | 3 | 9.2 | 1.6 ± 0.18 | 3 | 88 ± 17 | 3 | 55 | 7.2 | 43 | ||||||||
CXCL3/GROγ | 0.09 ± 0.01 | 5 | 1.7 ± 0.02 | 3 | 19 | 0.82 ± 0.16 | 3 | 69 ± 10 | 3 | 84 | 9.1 | 41 | ||||||||
Inverse agonists | ||||||||||||||||||||
CXCL10/IP10 | 2.6 ± 0.71 | 3 | 5.2 ± 1.7 | 4 | 2.0 | 0.66 ± 0.11 c | 15 | 0.73 ± 0.10 d | 9 | 1.1 | 0.25 | 0.14 | ||||||||
CXCL12/SDF1 | 13 ± 1.4 | 5 | 20 ± 5.2 | 2 | 1.5 | 11 ± 6.9 | 3 | 5.1 ± 2.2 | 3 | 0.4 | 0.87 | 0.25 | ||||||||
vCCL2/vMIP-II | 210 ± 111 | 4 | 87 ± 38 | 3 | 0.4 | 72 ± 8.8 | 7 | 38 ± 4.2 | 4 | 0.5 | 0.34 | 0.44 |