Expression of α4β2 receptors containing mutations in the ligand binding site
Data are expressed as in Table 1.
Data | No Drug | ||||
|---|---|---|---|---|---|
| Ratio to pcDNA3 | P vs 1 | P vs WT | |||
| WT | 2.6 ± 1.1 (26) | *** | |||
| α4 W182F | 1.5 ± 1.0 (9) | N.S. | * | ||
| α4 Y223F | 1.4 ± 0.6 (6) | N.S. | * | ||
| α4 Y126F | 2.3 ± 0.8 (10) | *** | N.S. | ||
| α4 Y230F | 2.8 ± 0.9 (6) | ** | N.S. | ||
| β2 W82F | 1.7 ± 0.9 (7) | N.S. | N.S. | ||
***, P < 0.001; **, P < 0.01; *, P < 0.05; N.S. P > 0.05 (see Materials and Methods).