TABLE 1
IC50 values of caulibugulones for inhibition of recombinant human protein phosphatases
All values are micromolar concentrations and are the mean ± S.E.M. of three or more independent determinations
Caulibugulone | Structure | Cdc25A | Cdc25Ba | Cdc25C | VHRa | PTP1Ba |
|---|---|---|---|---|---|---|
| A |
| 3.38 ± 0.62 | 6.74 ± 1.28 | 5.43 ± 1.22 | >1000 | >1000 |
| B |
| 1.51 ± 0.23 | 2.72 ± 0.51 | 2.68 ± 0.23 | 130 ± 23 | 183 ± 24 |
| C |
| 2.57 ± 0.60 | 5.40 ± 0.73 | 3.31 ± 0.28 | 175 ± 2 | 322 ± 32 |
| D |
| 4.89 ± 0.82 | 19.1 ± 0.25 | 10.8 ± 0.46 | >1000 | >1000 |
| E |
| 18.2 ± 1.13 | 32.5 ± 3.57 | 16.6 ± 0.98 | >1000 | >1000 |