Effect of test compounds on the ability of Raji/DC-SIGN cells to capture HIV-1(IIIB) particles
IC50 is the 50% inhibitory concentration or compound concentration required to prevent HIV-1 capture (adsorption) by Raji/DC-SIGN cells as measured by HIV-1 p24 ELISA determination in the virus-exposed Raji/DC-SIGN cell cultures after prior and careful removal of unadsorbed virus.
Test Compound | IC50 |
|---|---|
| μg / ml | |
| HHA | 8.5 |
| GNA | 18 |
| NPA | 0.7 |
| CA | 2.4 |
| CV-N | 0.035 |
| UDA | 10 |
| mAb 2G12 | 0.80 |
| mAb F105 | >5.0 |
| mAb 9205 | 0.20 |
| T-20 | >25 |
| AMD3100 | >50 |
| Maraviroc | >1.0 |
| CADA | >50 |
| DS-5000 | >250 |
| PVAS | >250 |
| PRO-2000 | >25 |