Influence of U0126 (2 × 5 μg/rat, i.t.) on transcript variations promoted by acetaminophen (400 mg/kg, p.o.) in the rat spinal cord
Results are expressed in -fold changes over saline-treated animals submitted to the formalin test (F). Experiments were performed in quadruplicate (n = 3).
FA | FU | FAU | |
|---|---|---|---|
| p75NTR | 1.84 ± 0.34* | 1.03 ± 0.15 | 1.74 ± 0.30* |
| IGF1Rα | 1.84 ± 0.34* | 1.25 ± 0.25 | 2.00 ± 0.40* |
| GHR | 1.97 ± 0.44* | 1.11 ± 0.22 | 2.39 ± 0.45* |
| SST3R | 0.50 ± 0.09* | 0.99 ± 0.23 | 0.98 ± 0.14# |
FA, acetaminophen-treated rats submitted to the formalin test; FU, U0126-treated rats submitted to the formalin test; FAU, rats treated with acetaminophen and U0126 and submitted to the formalin test.
↵* P < 0.05 vs. F determined by two-way general linear model followed by Tukey Honestly Significant Difference test.
↵# P < 0.05 vs. FA determined by two-way general linear model followed by Tukey Honestly Significant Difference test.