CLtotal | CLrenal,plasma | CLrenal,kidney | GFR | Kp,kidney | Kp,liver | Kp,brain | |
---|---|---|---|---|---|---|---|
ml/min/kg | |||||||
Wild type | 24.7 ± 1.2 | 23.7 ± 1.6 | 0.86 ± 0.04 | 12.9 ± 0.9 | 13.1 ± 0.7 | 0.82 ± 0.08 | 0.07 ± 0.02 |
Mrp4(−/−) | 18.8 ± 0.3** | 16.7 ± 0.2* | 0.32 ± 0.03** | 10.8 ± 0.3 | 19.5 ± 1.3* | 0.98 ± 0.20 | 0.09 ± 0.04 |
Kp, kidney; Kp, value obtained by dividing the kidney concentration by Css,plasma (at 90 min).
*P < 0.05 and **P < 0.01, statistically significant difference.