TABLE 1

Pharmacokinetic parameters of adefovir during constant infusion into wild-type and Mrp4 knockout mice

Data are taken from Fig. 7, A-C. Data represent the mean ± S.E. (n = 3).

CLtotal
CLrenal,plasma
CLrenal,kidney
GFR
Kp,kidney
Kp,liver
Kp,brain
ml/min/kg
Wild type 24.7 ± 1.2 23.7 ± 1.6 0.86 ± 0.04 12.9 ± 0.9 13.1 ± 0.7 0.82 ± 0.08 0.07 ± 0.02
Mrp4(−/−)
18.8 ± 0.3**
16.7 ± 0.2*
0.32 ± 0.03**
10.8 ± 0.3
19.5 ± 1.3*
0.98 ± 0.20
0.09 ± 0.04

  • Kp, kidney; Kp, value obtained by dividing the kidney concentration by Css,plasma (at 90 min).

    *P < 0.05 and **P < 0.01, statistically significant difference.