TABLE 3

Pharmacokinetic parameters of cidofovir during constant infusion into wild-type and Mrp4 knockout mice

Data are taken from Fig. 7, G-I. Data represent the mean ± S.E. (n = 3)




CLtotal

CLrenal,plasma

CLrenal,kidney

GFR

Kp,kidney

Kp,liver

Kp,brain
ml/min/kg
Wild type 34.4 ± 6.4 26.1 ± 5.7 0.53 ± 0.16 13.8 ± 2.5 22.2 ± 1.7 0.31 ± 0.03 0.045 ± 0.006
Mrp4(−/−)
42.7 ± 0.9
29.6 ± 0.5
0.60 ± 0.08
12.6 ± 0.4
27.3 ± 5.8
0.34 ± 0.04
0.056 ± 0.001
  • Kp, kidney; Kp, value obtained by dividing the kidney concentration by Css,plasma (at 90 min).