Substrate | hSGLT3 | hSGLT1 | ||||
---|---|---|---|---|---|---|
K0.5 | ΔEm(max) | K0.5 | ΔEm(max) | |||
mM | % αMDG | mM | % αMDG | |||
D-Glucose | 19 ± 6 | 108 ± 3 | 0.5 ± 0.02a | 83 ± 5a | ||
αMDG | 21 ± 6 | 100 | 0.7 ± 0.04a | 100 | ||
1DOglc | 43 ± 10 | 170 ± 20 | 10 ± 1a | 83 ± 5a | ||
2DOglc | N.D. | N.D. | >100a | 83 ± 5a | ||
3DOglc | N.D. | N.D. | N.D. | N.D. | ||
4DOglc | > 50 mM | Not Determined | 0.4 ± 0.05 | 100 ± 3 | ||
4D4Fglc | 17 ± 1 | 100 ± 4 | 0.07 ± 0.01a | 83 ± 5a | ||
D-Galactose | N.D. | N.D. | 0.6 ± 0.02a | 83 ± 5a | ||
4D4Fgal | N.D. | N.D. | 1.3 ± 0.09 | 110 ± 2 | ||
6-Deoxy-d-glucose | > 50 mM | Not Determined | 3 ± 0.5a | 83 ± 5a | ||
DNG | 0.004 ± 0.001 | 260 ± 36 | N.D. | N.D. | ||
DGJ | 11 ± 4 | 440 ± 74 | N.D. | N.D. | ||
NE-DNJ | 0.003 ± 0.001 | 130 ± 36 | N.D. | N.D. | ||
NEOH-DNJ (miglitol) | 0.003 ± 0.001 | 200 ± 22 | N.D. | N.D. | ||
NB-DNJ (miglustat) | 0.0005 ± 0.0001 | 88 ± 11 | N.D. | N.D. | ||
1SO-DNJ | 0.009 ± 0.004 | 100 ± 30 | N.D. | N.D. |