TABLE 2

K_iapp values for the inhibition of hiCE, hCE1, rCE, hAChE, or hBChE after preincubation of the enzymes with the TFK analogs for 5 min

Data were analyzed using Eq. 1 and are presented ± S.E.

ID	K_i
ID		hiCE	hCE1	rCE	hAChE	HBChE
			nM
1	15.0 ± 2.0^a	71.0 ± 7.0^b	160 ± 20^b	>100,000	1200 ± 300^c
2	54.0 ± 6.0^c	1900 ± 300^b	1100 ± 200^b	>100,000	>100,000
3	32.0 ± 2.0^c	740 ± 100^b	150 ± 20^a	>100,000	>100,000
4	150 ± 20^b	130 ± 20^b	160 ± 30^b	710 ± 110^c	10,800 ± 1500^b
5	1900 ± 300^b	5300 ± 100^b	2500 ± 200^b	>100,000	>100,000
6	80.0 ± 5.0^a	800 ± 130^b	220 ± 20^a	>100,000	>100,000
7	22 ± 1^c	150 ± 20^b	140 ± 10^b	>100,000	3800 ± 440^c
8	220 ± 40^b	190 ± 40^b	150 ± 30^b	1750 ± 220^c	11,500 ± 1100^b
9	2400 ± 700^b	14,700 ± 2900^b	4900 ± 1400^b	>100,000	>100,000
10	4700 ± 5000^b	1500 ± 300^b	4800 ± 800^b	>100,000	>100,000
11	560 ± 110^b	330 ± 80^b	250 ± 50^b	>100,000	18,400 ± 2900^c
12	67,900 ± 35,900^b	79,500 ± 3200^b	22,800 ± 12,400^b	>100,000	>100,000
13	27,500 ± 5800^b	9800 ± 1400^b	15,300 ± 1800^b	>100,000	>100,000
14	9100 ± 1600^b	3300 ± 1000^b	2700 ± 800^b	>100,000	>100,000
15	>100,000	>100,000	>100,000	>100,000	>100,000
16	>100,000	>100,000	>100,000	>100,000	>100,000
17	>100,000	>100,000	>100,000	>100,000	>100,000
18	1700 ± 300^b	800 ± 100^b	420 ± 50^b	2500 ± 100^c	>100,000
19	>100,000	>100,000	>100,000	>100,000	>100,000
20	750 ± 90^b	120 ± 20^c	410 ± 110^b	72,000 ± 37,000^b	65,600 ± 8000^b
21	50,700 ± 13,600^b	13,800 ± 3000^b	13,600 ± 2300^b	>100,000	>100,000

Modes of enzyme inhibition are:
↵ a Competitive
↵ b Partially noncompetitive.
↵ c Partially competitive.