Ki values for the inhibition of hiCE, hCE1, or rCE after preincubation of the enzymes with the TFK analogs for 24 h
Datasets were analyzed using the model applicable for slow binding inhibitors (eq 2). Data are presented as mean ± S.E.
ID | Ki | ||||
|---|---|---|---|---|---|
| hiCE | hCE1 | rCE | |||
| nM | |||||
| 1 | 5.4 ± 1.9 | 7.4 ± 1.5 | 3.3 ± 1.0 | ||
| 2 | 0.4 ± 0.1 | 0.4 ± 0.1 | 1.4 ± 0.2 | ||
| 3 | 1.0 ± 0.2 | 0.4 ± 0.1 | 0.7 ± 0.1 | ||
| 4 | 4.6 ± 1.2 | 4.0 ± 0.9 | 2.8 ± 0.4 | ||
| 5 | 0.5 ± 0.1 | 0.5 ± 0.1 | 3.0 ± 0.3 | ||
| 6 | 1.1 ± 0.3 | 0.3 ± 0.1 | 1.6 ± 0.2 | ||
| 7 | 2043.3 ± 146.8 | 2.3 ± 0.2 | 3236.6 ± 271.1 | ||
| 8 | 3.50 ± 0.6 | 4.2 ± 0.9 | 7.8 ± 0.9 | ||
| 9 | 0.5 ± 0.1 | 0.6 ± 0.1 | 6.4 ± 1.1 | ||
| 10 | 5.8 ± 1.7 | 0.6 ± 0.1 | 36.8 ± 7.8 | ||
| 11 | 6.5 ± 0.9 | 5.2 ± 1.1 | 9.9 ± 1.3 | ||
| 12 | 0.5 ± 0.2 | 3.3 ± 0.3 | 21.7 ± 3.4 | ||
| 13 | 3.7 ± 0.7 | 0.7 ± 0.1 | 34.3 ± 7.6 | ||
| 14 | 1.2 ± 0.2 | 1.0 ± 0.2 | 1.7 ± 0.1 | ||
| 15 | >100,000 | >100,000 | >100,000 | ||
| 16 | 577.9 ± 89.2 | 1840.8 ± 560.3 | 2516.3 ± 229.8 | ||
| 17 | >100,000 | >100,000 | >100,000 | ||
| 18 | 16.5 ± 1.9 | 5.4 ± 0.7 | 7.7 ± 1.2 | ||
| 19 | 2.0 ± 0.6 | 14.3 ± 4.2 | 137.3 ± 34.2 | ||
| 20 | 4.8 ± 0.9 | 6.4 ± 1.8 | 5.5 ± 0.8 | ||
|
21
| 116.2 ± 37.4 | 6.0 ± 1.3 | 106.4 ± 32.0 | ||