Pharmacokinetic parameters of plasma nicotine and cotinine in mice treated with nicotine (1 mg/kg, s.c.)
Results are derived using data from five to seven animals at each time point.
Nicotine | Cotinine | |||||
|---|---|---|---|---|---|---|
| DBA/2 | C57BL/6 | DBA/2 | C57BL/6 | |||
| AUC0-480 (ng · h/ml) | 92.9 ± 2.9* | 80.8 ± 3.2 | 245 ± 10* | 120 ± 7 | ||
| t1/2 (min) | 8.6 ± 0.4 | 9.2 ± 1.6 | 51.0 ± 4.1* | 23.7 ± 2.0 | ||
| CL / F (ml/min) | 4.5 ± 0.1* | 5.2 ± 0.2 | N.D. | N.D. | ||
| Tmax (min) | 10.0 ± 2.2 | 10.0 ± 4.7 | 45.0 ± 13.3* | 20.0 ± 13.3 | ||
| Cmax (ng/min) | 201 ± 15* | 160 ± 15 | 141 ± 7* | 112 ± 12 | ||
N.D., not determined.
↵* p < 0.05 compared with C57BL/6 mice.