TABLE 3

Pharmacokinetic parameters of plasma cotinine and 3′-hydroxycotinine in mice treated with cotinine (1 mg/kg, s.c.)

Results are derived using data from three to eight animals at each time point.



Cotinine

3′-Hydroxycotinine

DBA/2
C57BL/6
DBA/2
C57BL/6
AUC0-180 (ng · h/ml) 1087 ± 33* 796 ± 33 518 ± 30* 268 ± 19
t1/2 (min) 50.2 ± 4.7* 37.5 ± 9.6 N.D. N.D.
CL / F (ml/min) 0.38 ± 0.01* 0.52 ± 0.02 N.D. N.D.
Tmax (min) 15.0 ± 7.5 15.0 ± 0.0 60.0 ± 0.0 60.0 ± 23.6
Cmax (ng/ml)
748 ± 35
759 ± 39
255 ± 23*
110 ± 10
  • N.D., not determined.

  • * P < 0.05 compared with C57BL/6.