TABLE 4

In vitro cotinine hydroxylation parameters




DBA/2 (n = 4)

C57BL/6 (n = 4)
mean ± S.D.
Km (μM) 51.0 ± 15.6* 9.5 ± 2.1
Vmax (nmol/min/mg) 0.10 ± 0.01* 0.04 ± 0.01
Vmax/Km
0.002 ± 0.000*
0.005 ± 0.002
  • * p < 0.05 compared with C57BL/6 mice.