TABLE 1

Effects of pentobarbital on baseline ECG parameters

All values are mean ± S.E.M. Group sizes: pentobarbital: wt, n = 5; β3(N265M), n = 7; intravenous alphaxalone: wt, n = 6; β3(N265M), n = 6. If not indicated, the deviation from baseline or the genotype difference was not statistically significant.

Baseline
Pentobarbital Vehicle
Pentobarbital 60 mg/kg i.p.
Alphaxalone Vehicle
Alphaxalone 15 mg/kg i.v.
wt
β3(N265M)
wt
β3(N265M)
wt
β3(N265M)
wt
β3(N265M)
wt
β3(N265M)
ms
RR 107 ± 3.6 108 ± 4.7 130 ± 29 117 ± 3.5 285 ± 13.6** 138 ± 7.6*# 87 ± 0.5 93 ± 2 147 ± 9.7** 132 ± 2.9*
HRV 5.2 ± 0.8 5.4 ± 0.8 6.4 ± 2.8 3.2 ± 0.7 40.4 ± 5.8** 25.7 ± 6.2*# 1.8 ± 0.2 1.9 ± 0.3 18.1 ± 4.1* 12.3 ± 1.6*
QT 23.5 ± 0.6 19.7 ± 0.9 26 ± 1 24.1 ± 0.9 27.6 ± 1.3** 25.6 ± 1** 24.7 ± 0.7 26.5 ± 1 26.6 ± 0.8 24.9 ± 1
QRS 12.2 ± 0.5 11.2 ± 0.5 11.8 ± 0.6 11.1 ± 0.6 16 ± 2 13.8 ± 5* 11.3 ± 0.4 11.2 ± 0.5 14 ± 0.8 13 ± 1.2
PQ
31.8 ± 1.3
32.2 ± 0.7
33.8 ± 2.1
36.4 ± 2.7
43.8 ± 1.2***
43.1 ± 1.5***
32.7 ± 1.3
31.3 ± 0.9
44.6 ± 1*
43.9 ± 0.8*

  • RR, interbeat interval; wt, wild type.

  • ↵* p < 0.05, ** p < 0.01, *** p < 0.001 compared with baseline.

  • ↵# p < 0.05 wild-type compared with β3(N265M) mice