Drug | MES ED50 | Median Spread Areaa |
---|---|---|
mg / kg | μm2 | |
Control | NA | 70 |
3 mM VPA | 263b | 228*** |
2 mM LiCl | NA | 118** |
1 mM DIA | 238c | 191*** |
1 mM PIA | >300d | 102* |
1 mM VCA | 269c | 84 |
1 mM 4-ene-VPA | 350e | 95 |
1 mM 4-yne-VPA | NT | 83 |
3 mM DID | 87c | 65 |
3 mM PID | 122d | 73 |
3 mM VCD | 58c | 61 |
3 mM VPD | 56c | 52 |
1 mM MTMCD | 98f | 101* |
1 mM TMCUg | 90f | 51 |
3 mM TMCA | 194 | 78 |
3 mM TMCD | >120f | 62 |
NA, not active; NT, not tested.
↵ a The differences in the median values were analyzed by Kruskal—Wallis test, followed by Dunn's multiple comparison test of each drug treatment vs. control: *, p < 0.05; **, p < 0.01; ***, p < 0.001.
↵ g TMCU is insoluble at concentrations above 1 mM and therefore could only be tested at lower concentrations.