TABLE 1

Activity of VPA derivatives and analogs as anticonvulsants (MES test in mice; i.p.) and their effects on the median growth cone area from rat dorsal root ganglia

The abbreviations for the various compounds are given in Fig. 1.


Drug

MES ED50

Median Spread Areaa
mg / kg μm2
Control NA 70
3 mM VPA 263b 228***
2 mM LiCl NA 118**
1 mM DIA 238c 191***
1 mM PIA >300d 102*
1 mM VCA 269c 84
1 mM 4-ene-VPA 350e 95
1 mM 4-yne-VPA NT 83
3 mM DID 87c 65
3 mM PID 122d 73
3 mM VCD 58c 61
3 mM VPD 56c 52
1 mM MTMCD 98f 101*
1 mM TMCUg 90f 51
3 mM TMCA 194 78
3 mM TMCD
>120f
62
  • NA, not active; NT, not tested.

  • a The differences in the median values were analyzed by Kruskal—Wallis test, followed by Dunn's multiple comparison test of each drug treatment vs. control: *, p < 0.05; **, p < 0.01; ***, p < 0.001.

  • b Data from White et al. (2002)

  • c Data from Haj-Yehia and Bialer (1990).

  • d Data from Spiegelstein et al. (1999).

  • e Data from Loscher and Nau (1985).

  • f Data from Sobol et al. (2004).

  • g TMCU is insoluble at concentrations above 1 mM and therefore could only be tested at lower concentrations.