Compound | Schild Slope | pA2 | Kb | t a |
---|---|---|---|---|
nM | min | |||
Talnetantb | 1.3 ± 0.2 | 8.82 | 1.5 | 10 |
Talnetantc | 0.90 | 3.0 | ||
SB222200b | 0.92 | 3.3 | 10 | |
Osanetantb | 3.3 ± 0.3 | 7.94 | 12 | 10 |
3.1 ± 0.3 | 8.03 | 9 | 30 | |
| 2.9 ± 0.3 | 8.02 | 10 | 55 |
↵ a Preincubation time.
↵ b From this work with Kb values calculated from pA2.
↵ c From NKB-induced Ca2+ mobilization in human embryonic kidney 293 cells overexpressing human recombinant NK3 with Kb values calculated by averaging values estimated from displacement of agonist dose-response curve at various concentrations of antagonist (Sarau et al., 2000).