TABLE 2
Chemical structures and activity of the most potent activators of ROS production
Compound activation of ROS production is indicated for bone marrow leukocytes (BM), murine neutrophils (M PMN), and human neutrophils (H PMN).
Compound Number & Structure | AC50 | Compound Number & Structure | AC50 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BM | PMN | BM | PMN | ||||||||||
| M | H | M | H | ||||||||||
| μM | μM | ||||||||||||
| 1 |
| 0.1 | 0.05 | 8.31 | 14 |
| 6.2 | 24.7 | 38.6 | ||||
| 2 |
| 1.7 | 2.0 | 4.9 | 15 |
| 6.3 | 1.6 | 18.4 | ||||
| 3 |
| 1.9 | 26.8 | N.A. | 16 |
| 6.6 | 0.6 | N.A. | ||||
| 4 |
| 2.3 | 8.7 | 2.3 | 17 |
| 6.7 | 27.0 | N.A. | ||||
| 5 |
| 2.4 | 12.2 | 9.6 | 18 |
| 8.5 | 5.6 | N.A. | ||||
| 6 |
| 2.6 | 1.3 | N.A. | 19 |
| 8.6 | 12.0 | 17.3 | ||||
| 7 |
| 2.7 | 1.7 | N.A. | 20 |
| 8.9 | 11.8 | N.A. | ||||
| 8 |
| 2.8 | 1.7 | N.A. | 21 |
| 11.3 | 34.0 | N.A. | ||||
| 9 |
| 3.4 | 1.4 | 4.3 | 22 |
| 12.6 | 15.1 | 3.8 | ||||
| 10 |
| 3.6 | 15.0 | N.A. | 23 |
| 14.3 | 3.2 | 3.2 | ||||
| 11 |
| 3.6 | 7.1 | 7.1 | 24 |
| 15.2 | 3.8 | N.A. | ||||
| 12 |
| 3.7 | NA | N.A. | 25 |
| 16.7 | 1.3 | N.A. | ||||
|
13
|
| 4.5 | 4.1 | N.A. |
26
|
| 19.8 | 12.8 | 2.0 | ||||
-
N.A., cell activation was <50% of control level over a concentration range of 0 to 40 μM.