TABLE 3
Effect of selected test compounds on Ca2+ mobilization and chemotaxis in human neutrophils
Compound Number | EC50 | ||
|---|---|---|---|
| Ca2+ Mobilization | Chemotaxis | ||
| μM | |||
| 1 | 6.18 ± 0.13 | NA | |
| 2 | 5.08 ± 1.76 | 0.56 ± 0.38 | |
| 14 | 0.63 ± 0.39 | 0.042 ± 0.002 | |
| 22 | 23.64 ± 2.99 | 9.57 ± 1.13 | |
| 26 | 0.73 ± 0.22 | 12.55 ± 5.08 | |
| 30 a | 14.23 ± 1.45 | 10.90 ± 2.39 | |
| 104 | 12.20 ± 4.35 | 3.45 ± 0.20 | |
| fMLF | 0.005 ± 0.001 | 0.0005 ± 0.0001 | |
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↵ a Structure of compound 30:
