Classification of mitocans
Class Number | Type | Examples | References |
|---|---|---|---|
| I | Hexokinase inhibitors | 3-Bromopyruvate | Ko et al., 2004; Xu et al., 2005 |
| 2-Deoxyglucose | Ko et al., 2004 | ||
| II | Bcl-2/Bcl-xL mimetics | Gossypol | Kitada et al., 2003 |
| Antimycin A | Tzung et al., 2001 | ||
| α-Tocopheryl succinate | Shiau et al., 2006 | ||
| III | Thiol redox inhibitors | Isothiocyanates | Xu and Thornalley, 2001 |
| Arsenic trioxide | Miller, 2002 | ||
| IV | VDAC/ANT targeting drugs | Lonidamine, arsenites | Belzacq et al., 2001 |
| Steroid analogs such as CD437 | |||
| V | Electron transport chain targeting drugs | 4-OH retinamide | Hail and Lotan, 2001 |
| Tamoxifen | Moreira et al., 2006 | ||
| Antimycin A | Wolvetang et al., 1994 | ||
| VI | Lipophilic cations targeting inner membrane | Rhodamine-123 | Lampidis et al., 1983 |
| F16 | Fantin et al., 2002 | ||
| (KLAKKLAK)2 peptide | Ellerby et al., 1999 | ||
| VII | Drugs targeting other (unknown) sites | Resveratrol (ATPase ?) | Zheng and Ramirez, 1999 |
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| Betulinic acid |
Fulda et al., 1998
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