TABLE 3

Antiproliferative activity of vitamin E analogs with a modified hydrophobic domain

Compound Number
Functional Domain I (R1)
Signalling Domain II
Hydrophobic Domain III (R2)
IC50
Cell Type
References
μM
41 -O2CCH2CH2COO- Embedded Image COO- —a Jurkat, HBT11, MCF7, MCF7-C3 Birringer et al., 2003
42 HO- Embedded Image —a LNCaP, PC-3 Shiau et al., 2006
43 -O2CCH2CH2COO- 4-9
44 -O2CCH2CH2O- 4-8
45 -O2CCH2CH2COO- Embedded Image 8-19
46 CH3 >100
47 +NH3Lys(NH3)COO- CH2-OH 194 MCF7 Arya et al., 1998
48 CH2-O-nC5H11 22
49 CH2-OC(O)nC4H9 15
50 CH2-O-cholic acid 4
51 HO- CH2CH2COO- —b PC-3 Galli et al., 2004
52
HO-
Embedded Image
CH2CH2COO-
—c

  • ↵ a No effect.

  • ↵ b Weak inhibition at 50 μM.

  • ↵ c 82% inhibition at 10 μM.