TABLE 4

Antiproliferative activity of vitamin E analogs

Compounds are sorted by the signaling domain.


Compound Number

Functional Domain I (R1)

Signalling Domain II

Hydrophobic Domain III (R2)

IC50

Cell type

References
μM
53 HO- Embedded Image Embedded Image 210 MDA-MB-435 Guthrie et al., 1997
14 MCF7
110 B16(F10) He et al., 1997
54 CH3CH2COO- a A549 Yano et al., 2005
55 HO- Embedded Image b Jurkat, HBT11, MCF7, MCF7-C3 Birringer et al., 2003
56 HO- Embedded Image Embedded Image 4 Neoplastic + SA mammary epithelial cells Shah and Sylvester, 2005
15c MCF7 He et al., 1997
d Jurkat, HBT11, MCF7, MCF7-C3 Birringer et al., 2003
20 B16(F10) He et al., 1997
57 -O2CCH2CH2COO- e Jurkat, HBT11, MCF7, MCF7-C3 Birringer et al., 2003
f Prostate Vraka et al., 2006
58 -O2CCH2CH(SePh)COO- f Prostate Vraka et al., 2006
59 HO- Embedded Image 10 B16(F10) He et al., 1997
b MDA-MB-435, MCF7 Shun et al., 2004
15c MCF7 Nesaretnam et al., 1998
60
HO-
Embedded Image

0.9
B16(F10)
He et al., 1997
  • a Cytotoxic in 0 to 40 μM range.

  • b Very potent.

  • c Complete inhibition.

  • d Comparable with α-TOS.

  • e 2-Fold more potent than γ-tocotrienol.

  • f Inhibition of cell proliferation.