293B sensitivity of wild-type and chimeric KCNQ1/KCNQ2 channels
IC50 values are expressed as mean ± S.E.M. n indicates number of experiments.
Channel | IC50 | Inhibition at 100 μM 293B | n |
|---|---|---|---|
| μM | % | ||
| KCNQ1 | 26.9 ± 0.8 | 5 | |
| KCNQ2 | ∼5 | 3 | |
| Q1S5S6Q2 | ∼20 | 3 | |
| Q2S5S6Q1 | 56.2 ± 1.6 | 6 | |
| Q1S5Q2 | 38.7 ± 2.9 | 4 | |
| Q1S5linkerQ2 | 32.5 ± 2.1 | 3 | |
| Q1S5H5Q2 | ∼35 | 3 | |
| Q1H5S6Q2 |
| ∼10 | 3 |