TABLE 1

Affinities of CDPPB analogs at the allosteric mGluR5 antagonist MPEP binding site obtained from [³H]methoxyPEPy competition binding using membrane prep from the rmGluR5 stable cell line and their potencies as allosteric mGluR5 potentiators from glutamate-induced calcium release in cultured rat cortical astrocytes

Data are average ± S.E.M. from three or four independent experiments in duplicate.