EC50 values for dopamine release from striatal synaptosomes
Genotype/Subtype | EC50 | ||
|---|---|---|---|
| Nicotine | Cytisine | ||
| μM | |||
| Wild-type (α4+/+)(β3+/+) α-CtxMII-sensitive | 0.62 ± 0.19 | 0.024 ± 0.011 | |
| α4-null/β3-null (α4-/-)(β3-/-) | 21.24 ± 3.21 | 2.38 ± 0.56 | |
| α6α4β3β2 by subtraction | 0.23 ± 0.08 | 0.0080 ± 0.0033 | |
| α6β3β2 by subtraction | 1.52 ± 0.19 | 0.082 ± 0.032 | |
| C57BL/6 α-CtxMII-resistant | 1.61 ± 0.19a | 0.47 ± 0.09a | |