Antagonist | Kb | Reported Ki Values | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
α2A | α2B | α2C | α1A | α1B | α1D | |||||||
nM | nM | |||||||||||
Atipamezole | 1.7 ± 0.5 | 1.1a | 1.0a | 0.89a | 1300f* | 6500f* | N.A. | |||||
MK-912 | 4.8 ± 1.6 | 2.5b* | 1.3b* | 0.046c | N.A. | N.A. | N.A. | |||||
BRL-44408 | 15 ± 9.4 | 14b* | 480b* | 74c | 270g* | N.A. | N.A. | |||||
Yohimbine | 63 ± 15 | 43a | 6.9a | 2.6a | N.A. | 660h* | N.A. | |||||
ARC-239 | 540 ± 150 | 750d | 14b* | 47c | N.A. | N.A. | 0.39e | |||||
Prazosin | 4900 ± 1400 | 2500a | 36a | 80a | 0.3i | 0.2i | 0.3i | |||||
Terazosin | 5000 ± 1100 | N.A. | 7.8e* | N.A. | 3.9i | 1.9i | 3.4i |
N.A., not available
↵* Ki values from rat tissues were used if no rat αAR clone data was available.