EC50 values for the increase in the [Ca2+]i induced by PACAP-38, VIP, or maxadilan in CHO cells stably expressing the PAC1 isoforms
Maximum changes in the fluorescence signals from baseline were used to determine the responses to the agonists. Values are presented as mean ± S.E.
Expressed Receptor | EC50 (Increments of [Ca2+]i) | ||||
|---|---|---|---|---|---|
| PACAP-38 | Maxadilan | VIP | |||
| nM | |||||
| N/R | 1.30 ± 0.46 | 0.75 ± 0.14 | >10 | ||
| N/HOP1 | >10 | >1000 | >1000 | ||
| S/R | 1.28 ± 0.09 | 0.30 ± 0.04 | 4.38 ± 0.43 | ||
| S/HOP1 | 0.59 ± 0.56 | 0.61 ± 0.06 | >10 | ||