Binding affinities of diltiazem and metabolites at the human ghrelin receptor
Functional assays were performed as described under Materials and Methods. Values represent the means ± S.E.M.
| Ligand | pKi |
|---|---|
| Ghrelin | 10.4 ± 0.3 |
| GHRP-6 | 8.6 ± 0.0 |
| Hexarelin | 8.5 ± 0.0 |
| Diltiazem | 5.5 ± 0.1 |
| MA | 5.2 ± 0.1 |
| M1 | 6.1 ± 0.2 |
| M2 | 6.3 ± 0.2 |
| M4 | 5.2 ± 0.1 |
| M6 | 4.9 ± 0.0 |