TABLE 1

DA uptake inhibition in resealed bovine chromaffin granules

Data from Perera et al. (2003). The nonstandard Km, DA/Ki ratios were calculated from the respective Ki and Km, DA parameters determined for each compound to normalize the variation of Km for DA for different ghost preparations. These values also provide a measure of their relative abilities to compete with DA under the same experimental conditions.




Ki ± S.D.

Km, DA/Ki
μM
4′-OHAPP 15.5 ± 0.9 1.52
3′-OHAPP 16.7 ± 1.1 1.40
4′-FAPP 42.3 ± 3.1 0.80
4′-ClAPP 18.0 ± 0.9 1.76
4′-BrAPP 17.7 ± 2.0 1.79
4′-IAPP
12.9 ± 2.3
2.96