Effects of MS-PPOH and MAb-1 on peak current density and inactivation time constant The peak current density data under control conditions and after MS-PPOH and cAMP treatments were reported elsewhere in preliminary form (Xiao, 2007).
Wt | CYP2J2 Tr | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Peak | Inactivation (τfast) | Peak | Inactivation (τfast) | |||||||||||||||||||
| n | Mean | SE | n | Mean | SE | n | Mean | SE | n | Mean | SE | |||||||||||
| pA/pF | ms | pA/pF | ms | |||||||||||||||||||
| Control | 11 | 36.7 | 3.6 | 11 | 74.4 | 3.8 | 12 | 56.3 | 3.8 | 12 | 47.7 | 2.0 | ||||||||||
| MS-PPOH | 11 | 32.5 | 2.5 | 11 | 74.8 | 3.0 | 12 | 39.5** | 2.2 | 12 | 68.5** | 3.1 | ||||||||||
| cAMP | 11 | 33.6 | 3.3 | 11 | 72.7 | 4.2 | 12 | 53.4 | 3.9 | 12 | 49.2 | 2.2 | ||||||||||
| Initial | 9 | 38.8 | 2.6 | 9 | 80.2 | 3.5 | 7 | 57.2 | 3.1 | 7 | 49.0 | 3.1 | ||||||||||
| MAb-1 | 9 | 32.9 | 3.0 | 9 | 78.5 | 5.2 | 7 | 40.8** | 2.5 | 7 | 70.4** | 3.8 | ||||||||||
| cAMP | 9 | 35.2 | 3.0 | 9 | 77.1 | 6.1 | 7 | 52.1 | 3.3 | 7 | 66.6 | 3.8 | ||||||||||
| Initial | 9 | 40.0 | 2.9 | 9 | 77.8 | 4.3 | 11 | 55.8 | 2.7 | 11 | 46.3 | 2.5 | ||||||||||
| MAb-1 | 9 | 35.1 | 3.4 | 9 | 77.0 | 5.2 | 11 | 39.6** | 2.3 | 11 | 71.0** | 3.3 | ||||||||||
| EET | 9 | 39.8 | 3.5 | 9 | 73.2 | 5.8 | 11 | 54.9 | 3.0 | 11 | 46.1 | 2.9 | ||||||||||
Currents were elicited the 5-s test pulses from holding potential of –60 to +50 mV every 15 s
↵** p < 0.01